1968 March 19: Started a Cancer Institute at Kottayam Town in a rented building. Which was blessed by Arch Bishop Mar Mathew Kavukattu and inaugurated by Hon. Health Minister Mr. Willington.
1969 September 21: Started S.H.Medical Centre at Nagampadom in a new building and it was blessed and inaugurated by Arch Bishop Mar Mathew Kavukattu.
1970 JUNE 1 : Started Maternity department named as Madona Nursing Centre at Chunkam.
1971 September 21: Foundation stone laid for new building (P1, P2) by Rev.Fr.L.J.Chittoor.
1972 October 1: Bishop Dr. Cornelius Elanjikkal inaugurated the new building and blessed by Arch bishop Mar Antony Padiyara.
1976: Foundation stone for new building was laid by Mar Cornelius Elanjikal
1976: Cancer Institute became the part of Medical Centre.
1977 July 3: Inauguration and blessing of New building (OP, M1, M2) done by Arch Bishop Mar Antony Padiyara.
1987: Inauguration of New blocks (J, T, M, and OT).
1994: Started S.H. School of Nursing.
1994: Celebrated Jubilee of S.H. Medical Centre.
2014: S H Heart Institute was upgraded to diagnostic and Interventional Cardiology which was Inaugurated by Shri.Ramesh Chennithala Minister of Home affairs .
2015: BSc Nursing Programme Started with a strength of 40 Student in each batch
2015: S H Lions-Blood bank was inaugurated by Shri Oommen Chandy, Honarable Chief Minister of Kerala
2016: Thiruhrudaya College of Nursing was officialy Inaugurated by Shri Oommen Chandy, Honarable Chief Minister of Kerala